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產品詳情
操作說明
注意事項
Product Information
|
Description |
FCGRT/FCRN rabbit polyclonal |
|
Protein full name |
IgG receptor FcRn large subunit p51 |
|
Synonyms |
FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor, Fcgrt |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse FCGRT |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
40 kDa |
|
Observed MW. |
40 kDa |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Mouse |
1: 500-1: 1000 |
liver, kidney, small intestine |
Background
FcRN present in the intestinal epithelium of neonatal mice and rats mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn animals to acquire passive immunity. FcRn (also designated FCGRT, Brambell receptor, FcRn ? chain, IgG Gc receptor and neonatal Fc-receptor) is comprised of a heavy chain and ∫-2-Microglobulin. FcRn heavy chain shows approximately 35% amino acid identity to an MHC class I molecule. FcRN localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal catabolism. This protection mechanism is a major constituent for ensuring IgG are the longest lived of all plasma proteins.
Images
|
|
Western blot analysis of FCRN (GB112081) at dilution of 1: 1000 Lane 1: Mouse liver tissue lysate Lane 2: Mouse kidney tissue lysate Lane 3: Mouse small intestine tissue lysate |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥萬物生物科技有限公司
客服熱線：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區黃山路602號合肥國家大學科技園A401室