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產品詳情
操作說明
注意事項
Product Information
|
Description |
PARK7/DJ1 rabbit polyclonal antibody |
|
Protein full name |
Protein/nucleic acid deglycase DJ-1 |
|
Synonyms |
PARK7, DJ-1, DJ1, HEL-S-67p, Parkinsonism associated deglycase, GATD2 |
|
Immunogen |
Recombinant protein corresponding to Mouse PARK7 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
20 kDa |
|
Observed MW. |
24 kDa |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human, Mouse, Rat |
1: 500-1: 1000 |
heart, liver, kidney, brain |
Background
Protein deglycase DJ-1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene. Under an oxidative condition, protein deglycase DJ-1 inhibits the aggregation of α-synuclein via its chaperone activity, thus functions as a redox-sensitive chaperone and as a sensor for oxidative stress. Accordingly, DJ-1 apparently protects neurons against oxidative stress and cell death. In parallel, Protein DJ-1 acts as a positive regulator of androgen receptor-dependent transcription. Pyrroloquinoline quinone (PQQ) has been shown to reduce the self-oxidation of the DJ-1 protein, an early step in the onset of some forms of Parkinson's disease. Functional DJ-1 protein has been shown to bind metals and protect against metal-induced cytotoxicity from copper and mercury.
Images
|
Western blot analysis of cap (GB11640) at dilution of 1: 500
|
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥萬物生物科技有限公司
客服熱線：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區黃山路602號合肥國家大學科技園A401室