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產品詳情
操作說明
注意事項
Product Information
|
Description |
PFKL rabbit polyclonal antibody |
|
Protein full name |
ATP-dependent 6-phosphofructokinase, liver type |
|
Synonyms |
ATP-PFK, PFK-L, PFK-B, PFKL, 6-phosphofructokinase type B, Phosphofructo-1-kinase isozyme B |
|
Immunogen |
Recombinant protein corresponding to Human PFKL |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Cytoplasm |
|
Uniprot ID |
P17858 |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Human |
1: 1000-1: 3000 |
hepatocarcinoma, liver, prostate |
Background
PFKL is the Liver isozyme of PFK (Phosphofructokinase), which is a tetrameric enzyme that catalyzes a key step in glycolysis, namely the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate by ATP. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway.
Images
|
|
Immunohistochemistry of paraffin embedded human hepatocarcinoma using pfk1 (GB111136) at dilution of 1:1600 (400x lens) |
|
Immunohistochemistry of paraffin embedded human liver using pfk1 (GB111136) at dilution of 1:1600 (400x lens) |
|
|
Immunohistochemistry of paraffin embedded human prostate using pfk1 (GB111136) at dilution of 1:1600 (400x lens) |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥萬物生物科技有限公司
客服熱線：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區黃山路602號合肥國家大學科技園A401室