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Anti -NEDD4 Rabbit pAb
價(jià)格：
在線咨詢
貨號(hào)：
KT011934
產(chǎn)品規(guī)格：
100ul
Applications：
WB
Species：
M/R
購買數(shù)量：
產(chǎn)品詳情
操作說明
注意事項(xiàng)
Product Information
|
Description |
NEDD4 rabbit polyclonal antibody |
|
Protein full name |
E3 ubiquitin-protein ligase NEDD4 |
|
Synonyms |
HECT-type E3 ubiquitin transferase NEDD4, Kiaa0093, Neural precursor cell expressed developmentally down-regulated protein 4, Nedd4, Nedd4-1, Nedd4a |
|
Immunogen |
Recombinant protein corresponding to Mouse NEDD4 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
103 kDa |
|
Observed MW. |
120 kDa |
|
Uniprot ID |
P46935, Q62940 |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Mouse, Rat |
1: 500-1: 1000 |
brain, lung, cerebral cortex |
Background
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein. It contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in the pathway leading to the degradation of VEGFR-2/kDFR, independently of its ubiquitin-ligase activity. It acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. It is also reported to be involved in the budding of many viruses and is the regulator of epithelial Na+ channels, which lead to arterial hypertension. NEDD4 protein is localized to the sarcolemmal region of muscle fibers. Increase in NEDD4 protein expression leads to unloaded and denervated muscles as well as a decrease in Notch1 expression. Hence it acts as down regulator of Notch-1 gene expression.
Images
|
|
Western blot analysis of nedd4 (GB111057) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥萬物生物科技有限公司
客服熱線：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區(qū)黃山路602號(hào)合肥國家大學(xué)科技園A401室