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產品詳情
操作說明
注意事項
Product Information
|
Description |
RB-1 rabbit polyclonal antibody |
|
Protein full name |
Retinoblastoma-associated protein |
|
Synonyms |
pRb, Rb, pp105, Rb1 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse RB-1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Nucleus |
|
Uniprot ID |
P13405, P33568 |
Applications
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Applications |
Species |
Dilution |
Positive Sample |
|
IHC/IF |
Mouse, Rat |
1: 500-1: 2500 |
brain, kidney, lung, Skeletal muscle |
Background
RB1 belongs to the retinoblastoma protein family. It is a key regulator of entry into cell division that acts as a tumor suppressor. RB1 acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation.
Images
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Immunohistochemistry of paraffin embedded mouse brain using RB1 (GB111111) at dilution of 1:700 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse kidney using RB1 (GB111111) at dilution of 1:700 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse Skeletal muscle using RB1 (GB111111) at dilution of 1:1400 (400x lens) |
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Immunohistochemistry of paraffin embedded rat brain using RB1 (GB111111) at dilution of 1:1400 (400x lens) |
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Immunohistochemistry of paraffin embedded rat brain using RB1 (GB111111) at dilution of 1:700 (400x lens) |
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Immunohistochemistry of paraffin embedded rat kidney using RB1 (GB111111) at dilution of 1:1400 (400x lens) |
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Immunohistochemistry of paraffin embedded rat lung using RB1 (GB111111) at dilution of 1:700 (400x lens) |
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Immunofluorescence of paraffin embedded mouse Brain using RB1 (GB111111) at dilution of 1:1400 (400x lens) |
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Immunofluorescence of paraffin embedded mouse Skeletal muscle using RB1 (GB111111) at dilution of 1:1400 (400x lens) |
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Immunofluorescence of paraffin embedded rat brain using RB1 (GB111111) at dilution of 1:1400 (400x lens) |
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Immunofluorescence of paraffin embedded rat kidney using RB1 (GB111111) at dilution of 1:1400 (400x lens) |
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Immunofluorescence of paraffin embedded rat lung using RB1 (GB111111) at dilution of 1:1400 (400x lens) |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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合肥萬物生物科技有限公司
客服熱線：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區黃山路602號合肥國家大學科技園A401室