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產品詳情
操作說明
注意事項
Product Information
|
Description |
Kir6.2 rabbit polyclonal antibody |
|
Protein full name |
ATP-sensitive inward rectifier potassium channel 11 |
|
Synonyms |
Inward rectifier K(+) channel Kir6.2, Potassium channel, Kcnj11, inwardly rectifying subfamily J member 11 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse Kir6.2 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
44 kDa |
|
Observed MW. |
44 kDa |
|
Uniprot ID |
Q61743, P70673 |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Mouse, Rat |
1: 500-1: 1000 |
heart, brain |
Background
Kir6.2 (also known as BIR or IKATP), encoded by the KCNJ11 gene, is the pore-forming unit of the ATP-sensitive K+ channel, an inward-rectifier potassium ion channel. Kir6.2 is controlled by G-proteins and is found associated with the sulfonylurea receptor (SUR) to constitute the ATP-sensitive K+ channel. The KCNJ11 gene is located at 11p15.1 and has no intron. Mutations in KCNJ11 are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in KCNJ11 may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM).
Images
|
|
Western blot analysis of KCN11 (GB111084) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥萬物生物科技有限公司
客服熱線：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區黃山路602號合肥國家大學科技園A401室