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400-1016-218
聯系方式
- 手機：400-1016-218
- Q Q：355185756
- 郵箱：355185756@qq.com
- 地址：安徽省合肥市高新區黃山路602號合肥國家大學科技園A401室
產品詳情
操作說明
注意事項
Product Information
|
Description |
AMPK gamma 1 rabbit polyclonal antibody |
|
Protein full name |
5'-AMP-activated protein kinase subunit gamma-1 |
|
Synonyms |
AMPK gamma1, AMPK subunit gamma-1, AMPKg, Prkag1, Prkaac |
|
Immunogen |
Recombinant protein corresponding to Mouse AMPK gamma 1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
38 kDa |
|
Observed MW. |
38 kDa |
|
Uniprot ID |
O54950, P80385 |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Mouse, Rat |
1: 500-1: 1000 |
heart, brain, muscle |
Background
AMP/ATP-binding subunit of AMP-activated protein kinase, an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits.
Images
|
|
Western blot analysis of AMPK-γ1at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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合肥萬物生物科技有限公司
客服熱線：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區黃山路602號合肥國家大學科技園A401室