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400-1016-218
聯系方式
- 手機：400-1016-218
- Q Q：355185756
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- 地址：安徽省合肥市高新區黃山路602號合肥國家大學科技園A401室
產品詳情
操作說明
注意事項
Product Information
|
Description |
AKT1 rabbit polyclonal antibody |
|
Protein full name |
RAC-alpha serine/threonine-protein kinase |
|
Synonyms |
AKT1 kinase, Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, Akt1, Thymoma viral proto-oncogene, Akt |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Rat AKT1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
56 kDa |
|
Observed MW. |
60 kDa |
|
Uniprot ID |
P31749, P31750, P47196 |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human, Mouse, Rat |
1: 500-1: 1500 |
heart, brain |
Background
The AKT1 protein plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4.This protein is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
Images
|
|
Western blot analysis of AKT1 at dilution of 1: 500
|
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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合肥萬物生物科技有限公司
客服熱線：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區黃山路602號合肥國家大學科技園A401室