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產品詳情
操作說明
注意事項
Product Information
|
Description |
Lin28A rabbit polyclonal antibody |
|
Protein full name |
Protein lin-28 homolog A |
|
Synonyms |
Lin-28A, Testis-expressed protein 17, Lin28a, Lin28, Tex17 |
|
Immunogen |
Recombinant protein corresponding to Mouse Lin28A |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
23 kDa |
|
Observed MW. |
28 kDa |
|
Uniprot ID |
Q8K3Y3 |
Applications
|
Applications |
Species |
Dilution |
Positive Sample |
|
WB |
Mouse, Rat |
1: 500-1: 1000 |
liver, skeletal muscle, testis |
Background
LIN28A/B are expressed in various cancers and ES cells. LIN28 is a cytoplasmic protein, that acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. LIN28 is a negative regulator of microRNA (miRNA) biogenesis by specifically binding the precursor of let-7 (pre-let-7). Let-7 miRNAs have been implicated in repression of oncogenes such as ras and myc. LIN28 expression decreases during differentiation of ES cells or upon induction of neuronal differentiation by retinoic acid.
Images
|
|
Western blot analysis of Lin28A (GB111416) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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合肥萬物生物科技有限公司
客服熱線：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區黃山路602號合肥國家大學科技園A401室